Hyperbilirubinemia Neurotoxicity Risk Factors

• Gestational age < 38 weeks. This risk increases with the degree of prematurity^*
• Albumin < 3.0 g/dL
• Isoimmune hemolytic disease (ie, positive direct antiglobulin test), G6PD deficiency, or other hemolytic conditions
• Sepsis
• Significant clinical instability in the previous 24 hours

^*Gestational age is required to identify the phototherapy thresholds and the exchange transfusion thresholds.

← Please refer to these threshold graphs linked under "AAP Guidelines" in the dropdown menu on the left.

Source: Table 2: Hyperbilirubinemia Neurotoxicity Risk Factors from the AAP.